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  • 1 of 1 people found the following review helpful

    Meal Replacement & Protein Average overall rating: 2.5
    Monday, 23 January 2017

    Written by Anonymous

    Overall rating
    3.2
    Muscle gain
    3.0
    Strength
    2.5
    Taste
    5.0
    Mixes well
    3.0
    Safety
    3.0
    Suppressed appetite
    5.0
    Increased appetite
    0.5
    Recovery ability
    3.0
    Low side effects
    4.0
    Physical energy
    4.0
    Value for money
    4.0
    Ingredient profile
    2.5
    Recover Whey Protein Bar This is the best tasting protein bar that I have had. I do not eat these for the workout recovery but for the protein and suppressed appetite.
    Was this review helpful to you? yes     no
    2 months ago
  • admin updated a review for Listerine Listerine Zero

    2 of 2 people found the following review helpful

    Health & Wellness Average overall rating: 1.4
    Wednesday, 21 September 2016

    Written by admin - Top 50 reviewer - View all my reviews

    Overall rating
    1.4
    Low side effects
    0.5
    Taste
    4.0
    Safety
    0.5
    Value for money
    0.5
    Ingredient profile
    0.5
    Listerine Zero There isn’t a proper category for this product, as it’s not a supplement. However, I felt compelled to provide a review of it.

    It’s a litlte strange how Listerine Zero got such high reviews and ratings on the Canadian Listerine site (http://www.listerine.ca/products/classic-clean/classic-clean-zero), but not anywhere close on the .com site (https://www.listerine.com/mouthwash/alcohol-free/listerine-zero-mouthwash), where it garnered 1 out of 5 stars for 41 of the 126 reviews. One wonders why…

    I started searching the reviews after I had been given a free sample and started using it, and getting some nasty effects that I could liken to another product I had used years earlier. That product was Miracle Mineral Solution (MMS for short), which I reviewed here: http://www.supplementarium.com/supplements/817-miracle-mineral-solution-mms/reviews.

    MMS is basically sodium chlorite, an industrial cleaning agent. I found that it caused the tissues in my mouth to slough off, and I could literally feel them coming off on my tongue as I ran my tongue along the sides of my mouth. A similar thing happened with Listerine Zero. If you look at the ingredients, it has sodium lauryl sulfate (SLS) listed as an “inactive ingredient”. Supposedly, the “4 essential signature oils” comprise the active ingredients, and are responsible for keeping one’s breath fresh. I would argue that it’s the sodium lauryl sulfate that is doing most of the work, killing the bacteria - and, unfortunately, destroying other good tissue in the process.

    Even the top positive review on Amazon (https://www.amazon.com/product-reviews/B003QH1P6W/ref=cm_cr_arp_d_hist_1?pageNumber=1&filterByStar=one_star) mentions "possible mouth peeling", and there are plenty of negative reviews there that describe the skin peeling effects.

    Another reviewer on the Listerine.com site identified SLS as the cause of huge chunks of cheek and gum tissue to be coming off; it was also confirmed by this reviewer’s dentist. SLS is an industrial detergent and known irritant, which you can read more about here: http://slsfree.net (and many other sites, if you search around).

    All that Johnson and Johnson, the company behind this product, would respond to these negative reviews was how they want to gather additional information from and speak with the reviewers directly. However, that was over a year ago, and the product is still on our supermarket shelves, being bought and used by the unsuspecting public. I find it utterly disgraceful that such a dangerous product is allowed to be sold.

    Use Listerine Zero at your peril!
    Was this review helpful to you? yes     no
    6 months ago
  • admin added a new review for Listerine Listerine Zero

    2 of 2 people found the following review helpful

    Health & Wellness Average overall rating: 1.4
    Wednesday, 21 September 2016

    Written by admin - Top 50 reviewer - View all my reviews

    Overall rating
    1.4
    Low side effects
    0.5
    Taste
    4.0
    Safety
    0.5
    Value for money
    0.5
    Ingredient profile
    0.5
    Listerine Zero There isn’t a proper category for this product, as it’s not a supplement. However, I felt compelled to provide a review of it.

    It’s a litlte strange how Listerine Zero got such high reviews and ratings on the Canadian Listerine site (http://www.listerine.ca/products/classic-clean/classic-clean-zero), but not anywhere close on the .com site (https://www.listerine.com/mouthwash/alcohol-free/listerine-zero-mouthwash), where it garnered 1 out of 5 stars for 41 of the 126 reviews. One wonders why…

    I started searching the reviews after I had been given a free sample and started using it, and getting some nasty effects that I could liken to another product I had used years earlier. That product was Miracle Mineral Solution (MMS for short), which I reviewed here: http://www.supplementarium.com/supplements/817-miracle-mineral-solution-mms/reviews.

    MMS is basically sodium chlorite, an industrial cleaning agent. I found that it caused the tissues in my mouth to slough off, and I could literally feel them coming off on my tongue as I ran my tongue along the sides of my mouth. A similar thing happened with Listerine Zero. If you look at the ingredients, it has sodium lauryl sulfate (SLS) listed as an “inactive ingredient”. Supposedly, the “4 essential signature oils” comprise the active ingredients, and are responsible for keeping one’s breath fresh. I would argue that it’s the sodium lauryl sulfate that is doing most of the work, killing the bacteria - and, unfortunately, destroying other good tissue in the process.

    Even the top positive review on Amazon (https://www.amazon.com/product-reviews/B003QH1P6W/ref=cm_cr_arp_d_hist_1?pageNumber=1&filterByStar=one_star) mentions "possible mouth peeling", and there are plenty of negative reviews there that describe the skin peeling effects.

    Another reviewer on the Listerine.com site identified SLS as the cause of huge chunks of cheek and gum tissue to be coming off; it was also confirmed by this reviewer’s dentist. SLS is an industrial detergent and known irritant, which you can read more about here: http://slsfree.net (and many other sites, if you search around).

    All that Johnson and Johnson, the company behind this product, would respond to these negative reviews was how they want to gather additional information from and speak with the reviewers directly. However, that was over a year ago, and the product is still on our supermarket shelves, being bought and used by the unsuspecting public. I find it utterly disgraceful that such a dangerous product is allowed to be sold.

    Use Listerine Zero at your peril!
    Was this review helpful to you? yes     no
    6 months ago
  • Bull Terrier replied to the topic 'Why did datbtrue not allow his site to continue?' in the forum.
    Saying that the moderators don't have admin rights and thus are unable to retrieve the content of the datbtrue forum is just conjecture.
    It could be true, but outside of Dat and the moderators themselves I don't know how anybody else could possibly know.
    I'm quite sure of one thing though - at least one of the moderators has clear intentions to set up another forum and get back the old datbtrue members.

    Read More...
    6 months ago
  • admin replied to the topic 'Why did datbtrue not allow his site to continue?' in the forum.
    Bull Terrier wrote:
    I think that Datbtrue has done enough for plenty of people to merit a bit of trust and good faith. If he says he's closing for serious health problems i think we should believe him.
    As for archiving the site, this is being done by his moderators and they intend to get forum members onto another forum.
    I have no reason to doubt good faith of Datbtrue.

    We don't know yet though, whether admin rights were given to the moderators so that they can retrieve the content. Some people have said that this wasn't done, hence the topic of this thread.

    I should have stated more clearly that the topic is more about why the content wasn't allowed to continue, as in, to be moved to another site. We all know that the original site was being shut down.

    Read More...
    6 months ago
  • Bull Terrier replied to the topic 'Why did datbtrue not allow his site to continue?' in the forum.
    I think that Datbtrue has done enough for plenty of people to merit a bit of trust and good faith. If he says he's closing for serious health problems i think we should believe him.
    As for archiving the site, this is being done by his moderators and they intend to get forum members onto another forum.
    I have no reason to doubt good faith of Datbtrue.

    Read More...
    6 months ago
  • admin replied to the topic 'Why did datbtrue not allow his site to continue?' in the forum.
    As of today, www.datbtrue.co.uk has been wiped off the DNS database. It's not coming back, even temporarily.

    Read More...
    6 months ago
  • admin replied to the topic 'Why did datbtrue not allow his site to continue?' in the forum.
    Unfortunately I don't believe that anybody was able to archive the site. He closed it down yesterday - one day earlier than originally planned - quite possibly to prevent anybody from doing this.

    It's sad that such a vast body of knowledge contributed by Dat - as well as many others - could very well be lost.

    Losing not only this knowledge, but the person behind it all, is a terrible blow to all of humanity.

    Read More...
    6 months ago
  • admin replied to the topic 'Why did datbtrue not allow his site to continue?' in the forum.
    There's a thread on Reddit going on about this too: www.reddit.com/r/bodybuilding/comments/5...or_visited_datbtrue/.

    Someone posted a good comment there on why he might have shut it down so suddenly. It could be that he didn't have much faith in all the research he had done, his illness still progressed to the point it's at now. Who knows, he may have thought that his use of the IGF-1 LR3 hastened the illness?

    So he could have pulled the plug with the notion that other people don't get misinformed on the benefits of IGF-1, etc.

    Read More...
    6 months ago
  • kkc36392 replied to the topic 'Why did datbtrue not allow his site to continue?' in the forum.
    It would be such a shame to see it disappear :(

    My speculation is that it is already sold or passed on to another site or someone has bought the rights to the material already??

    Read More...
    6 months ago
  • admin created a new topic ' Why did datbtrue not allow his site to continue?' in the forum.
    This thread is about the controversy surrounding Datbtrue's site - datbtrue.co.uk - why do you think he didn't give the credentials to a mod or two to either allow it to continue, or to have the content from it archived or passed onto another site?

    No doubt some people will say it's because of legal issues. Let's hear your thoughts!

    Read More...
    6 months ago
  • Bull Terrier replied to the topic 'Testosterone and Anavar' in the forum.
    I'm calling BS on the article pulled from steroidology in opening post. Stanozolo has been shown to increase collagen synthesis (www.ncbi.nlm.nih.gov/pubmed/9856839) but I can't find any credible information in scientific literature that testosterone inhibits collagen synthesis. Actually if anything it has a positive effect:

    www.ncbi.nlm.nih.gov/pubmed/1529802
    "Abstract
    Testosterone and its metabolite 5 alpha-dihydrotestosterone (DHT) were compared with dexamethasone 21-acetate in two different animal models of arthritis and found to have effects on cartilage breakdown and inflammation. In the mouse air pouch, at the three dose levels used, significant effects were obtained with DHT and were more pronounced on cartilage breakdown than on inflammation. At the lowest dose of 0.3 mg kg-1 there was a 64% inhibition of collagen breakdown and 18% inhibition of glycosaminoglycans (GAGs) breakdown. In the antigen-induced arthritis mouse model testosterone had significant inhibitory effects on inflammation (synovial hyperplasia) and cartilage erosion."

    www.ncbi.nlm.nih.gov/pmc/articles/PMC3975417/
    "........The notion that testosterone decreases joint laxity is further supported by the reported increase in the collagen content of the prostate, breast and capsular tissue and an increase in knee ligament repair strength by testosterone "

    Personally I would be surprised if there were to be any information in scientific literature investigating the effect of boldenone and collagen synthesis in humans, considering that it is a veterinary drug.

    Read More...
    1 year ago
  • repellent replied to the topic 'IGF1 vs IGF1 LR3' in the forum.
    www.ncbi.nlm.nih.gov/pubmed/12746901

    These findings reveal a new paradigm by which IGF-1 influences chondrocyte metabolism, by reversing the IL-1-mediated catabolic pathway through up-regulation of its decoy receptor.

    Read More...
    1 year ago
  • repellent replied to the topic 'FGF-18 stimulates intestinal proliferation' in the forum.
    Yes I agree this is systemic

    Read More...
    1 year ago
  • admin created a new topic ' FGF-18 stimulates intestinal proliferation' in the forum.
    FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation
    To examine its biological activity in vivo, rMuFGF-18 was injected into normal mice and ectopically overexpressed in transgenic mice by using a liver-specific promoter. Injection of rMuFGF-18 induced proliferation in a wide variety of tissues, including tissues of both epithelial and mesenchymal origin. The two tissues which appeared to be the primary targets of FGF-18 were the liver and small intestine, both of which exhibited histologic evidence of proliferation and showed significant gains in organ weight following 7 (sometimes 3) days of FGF-18 treatment. Transgenic mice that overexpressed FGF-18 in the liver also exhibited an increase in liver weight and hepatocellular proliferation. These results suggest that FGF-18 is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine.

    This had me a little worried until I read the full text:
    Treatments consisted of intraperitoneal injections with either 5 mg of rMuFGF-18 or vehicle per kg.

    So we're talking about injection into an area that will likely cause a more systemic reaction, and a dose that is orders of magnitude higher than what is used to regenerate cartilage in knees, for instance (where it is injected IA).

    Not too much of a cause for concern IMO.

    Read More...
    1 year ago
  • admin replied to the topic 'Testosterone and Anavar' in the forum.
    Here's a couple of good pieces of info I found (thanks to your private message):

    First a patent:

    Uses of oxandrolone
    The subject invention additionally provides a method of promoting cartilage repair in a patient which comprises administering an oxandrolone to the patient.
    EXAMPLE 1: The effect of oxandrolone on inflammation

    The rat model of carrageenan-induced paw edema is used to assay the anti-inflammatory activity of oxandrolone. In this model, rats are given a sub-plantar injection of carrageenan into the left hind paw. The paw volume is measured by a Hg-displacement volumeter before and at hourly intervals after paw injection. Rats are divided into three groups. One group receives a subcutaneous injection of oxandrolone long before carrageenan administration. A second group receives a subcutaneous injection of oxandrolone closer to carrageenan administration. The other group does not receive any pretreatment and serves as a control.

    The swelling response is reduced indicating efficacy of oxandrolone as an anti-inflammatory agent.

    EXAMPLE 2 : The effect of oxandrolone on Synovial Inflammation

    As a model for synovial inflammation and the ability of oxandrolone to inhibit such inflammation, the knee-joint (synovial) inflammation model in rats is utilized. (Ginsburg et al . , in "Bayer-Symposium VI: Experimental Models of Chronic Inflammatory Diseases", 256-299, 1977, Springer-Verlag) .

    In this model, inflammation is induced by intraarticular injection of bacterial lipopolysaccharide endotoxin (LPS) . The degree of inflammation is reflected by the swelling of the synovial tissue and is measured as the increase in weight postadministration. The LPS toxin and oxandrolone are co-administered.

    The LPS-induced synovial inflammation is inhibited which indicates efficacy of oxandrolone as an inhibitor of synovial inflammation.

    EXAMPLE 3: The effect of Oxandrolone on Adjuvant-Induced Arthritis

    The induction of joint inflammation in rats by administration of Freund's adjuvant is considered to be the model of choice for experimental rheumatoid arthritis (Newbould (1963), Brit. J. Pharmacol. 21: 127). An injection of the adjuvant (Freund's adjuvant with killed Mycobacterium Tuberculosis) into the foot pad results in an initial swelling of the paw, reaching a plateau after 3 days, followed after 14 days by a second increase in,paw and joint swelling, which persists for another 7-10 days. The second phase is regarded as the phase of immunologically- induced chronic arthritis. To examine the efficacy of oxandrolone as an anti-arthritic drug, oxandrolone is given subcutaneously (in doses expressed as mg per kg body weight) to adjuvant-treated rats during 14-21 days after adjuvant administration. Oxandrolone is given daily or on alternating days. As a negative control, saline is given subcutaneously to a second group of adjuvant-treated rats.

    Joint inflammation is reduced which indicates efficacy of oxandrolone as an inhibitor of arthritis.

    And if we wish to delve into the mechanisms of its action, there is the following:

    Dynamics of Bone and Cartilage Metabolism: Principles and Clinical Applications
    Androgens have been shown to inhibit IL-6 production by stromal and osteoblastic cells as well as stimulation of osteoclastogenesis by marrow osteoclast precursors [125, 126].

    Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study.
    CONCLUSION: This followup study showed that individuals were more likely to be diagnosed as having RKOA if they had a higher BMI and increased circulating levels of IL-6. These results should stimulate more work on IL-6 as a potential therapeutic target.

    Also found this interesting piece:

    The Role of IL-6 in Osteoarthritis and Cartilage Regeneration
    DISCUSSION
    This study demonstrates the increased presence of IL-6 in the synovial fluid of patients with symptomatic cartilage lesions and OA donors when compared to healthy donors. Furthermore, we demonstrated for the first time that chondrocytes produce high concentrations of IL-6 during regeneration, especially osteoarthritic chondrocytes. However, IL-6 does not seem to play a direct role in cartilage matrix turnover. Furthermore, only in OA chondrocytes, IL-6 does seem to play a role in proliferation, although the effect was
    different in explants in the presence of synovial fluid compared to 3D differentiation by expanded chondrocytes.

    SIGNIFICANCE
    Soluble mediators, including IL-6, in the synovial fluid of knees with symptomatic cartilage defects are thought to cause progression to osteoarthritis and also hamper cartilage regeneration after cartilage surgeries such as autologous chondrocyte implantation. Identifying and targeting those soluble mediators will increase the success of cartilage
    repair surgery and prevent the progression to early osteoarthritis.


    Read More...
    1 year ago
  • admin replied to the topic 'Testosterone and Anavar' in the forum.
    Here's a couple of good things I found (thanks to your other one):

    Dynamics of Bone and Cartilage Metabolism: Principles and Clinical Applications

    Read More...
    1 year ago
  • repellent replied to the topic '2005 study on FGF-18' in the forum.
    In nearly all areas, repair tissue appeared to integrate well with the margins of the remaining normal cartilage.

    I think this is important, I also think that after cartilage is formed perhaps prp may enhance its ability to differentiate into more hyaline like tissue. The manufacturers website states they develop hyaline tissue; nonetheless fibro cartilage is still functional aslong as it doesn't wear away, and treatments with FGF-18 may prevent that. I'm really positive about this drug which may be due for release in USA by 2021, not far away. Obviously OA is a slow moving process in most cases; I have read studies wherby moderate hip OA doesn't progress for a period of 8 years, so hopefully just have to bind our time
    Read More...
    1 year ago
  • repellent replied to the topic 'Ember Therapeutics phase 2 knee trial' in the forum.
    Yes I feel BMP-7 is a powerful drug and just grows anything. There was a company advert which highlighted how excess cartilage from BMP7 had to be removed from the joint (in animal study), but thats the power if it growing tissue. I suppose the trouble in an OA joint is in some parts we have bone where we want cartilage and it may cause excessive bone growth in these areas. Perhaps with surgical intervention, i.e microfracture it may come into it's own, but again just an opinion
    Read More...
    1 year ago
  • repellent replied to the topic 'IGF1 vs IGF1 LR3' in the forum.
    I think its saying that as we age we have reduced response to dea(1-3), but this doesn't change the fact that we have increased response to des(1-3) IGF-1 in the OA joint, it summarizes with "the mechanism of the reduced response with age cannot be attributed to changes in IGFBP. Age-related changes in IGF receptors or, more likely, age-related alterations in intracellular signal transduction may also be involved."

    So my theory is ( and it is just a theory ) that des(1-3)IGF-1 is better for joints than IGF-1; this may also be the case with LR3-IGF1. But Des(1-3) is readily available
    Read More...
    1 year ago

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