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  • Being in optimal ketosis for a chronic time period (say, a month) will be sure that you experience the maximal hormonal impact from consuming a low-carb diet. Some folks concern that they will lose control if they don't eat every three hours, thus making them eat 1000's of calories and blowing their diets fully. A eating regimen based mostly mostly on meat and vegetables comprises all of the fiber, nutritional vitamins and minerals it's essential be healthy.

    Should you're on a low-carb food plan , feel free to eat fatty meats. Blood sugar tends to go approach down on low-carb diets ( 31 ). All of these interventions included dietary adjustments, and the added weight-loss profit from activity was small. Research on low-carb diets present that you could even gain a bit of muscle whereas losing significant amounts of body fat ( thirteen ).

    Dieters can have the occasional treats and doesn't promote calorie counting for weight loss. The checklist of low-energy, http://es.nucourt.eu/ filling foods can help to advertise a wholesome, varied and balanced eating regimen including plenty of fruit and vegetables. Avocados are wealthy in monounsaturated fatty acids, dietary fiber, potassium and phytochemicals. The problem of a slowing metabolism, and the desire to eat extra, occurs in each cases, http://nucourt.eu/ though dietary change nonetheless works better than exercise.

    Not like the Atkins weight loss plan, http://eiil.eu/ Dukan's phase 1 bans vegetables and seriously restricts fats. A brand new examine has revealed that a eating regimen rich in protein and low in calories might help older adults with weight problems lose more weight while sustaining muscle mass and enhancing bone density. Summary Although fruits comprise some sugar, http://balcic.eu/ you possibly can simply embrace them on a weight reduction food regimen.

    Slimming World's weight loss plan encourages you to swap excessive-fats foods for naturally filling low-fats ones. Low in energy and excessive in fibre, http://nucourt.eu/ pumpkin is without doubt one of the best vegetables to include in your weight loss weight loss program. Carrots are the most effective low-calorie greens to incorporate in your weight loss food regimen. There are various research that show that including exercise to diets may be helpful.

    Current human and canine research show that the omega-three fatty acids EPA and DHA from fish oil promote weight reduction and help dieters feel extra happy. At first of the weight-reduction plan, you might experience uncomfortable side effects comparable to dangerous breath, a dry mouth, tiredness, dizziness, insomnia and nausea from cutting out carbs. Combining a low-fat, low glycemic-index weight loss plan with exercise.

    Doing this on a low-carb weight loss program signifies that the fat you eat can be burned as gasoline by your physique, as your levels of the fat storing hormone insulin shall be lowered. Another eight-week study discovered that eggs for breakfast increased weight loss on a calorie restricted eating regimen, compared to bagels (). The idea of the alkaline weight loss plan is that eating certain foods can help keep the physique's superb acidity ranges to enhance general health.

    The alkaline eating regimen is predicated on the concept that fashionable diets trigger our physique to provide too much acid. Consuming chili peppers may be helpful on a weight loss weight loss plan. Abstract Leafy greens are an excellent addition to your weight loss weight loss plan. It's common to lose 2-6 kilos (1-three kg) inside the first week on a strict low-carb weight-reduction plan, and then on average about one pound (0.5 kg) per week as long as you've a lot of weight remaining to lose.

    Numerous research show that meals and diets with a low energy density make people eat fewer energy overall (). This is proven to make you lose as much as 2-three occasions as a lot weight as a typical low-fats, calorie-restricted weight loss plan ( 38 , 39 , ). Slimming World focuses on Food Optimising, which consists of three steps: free foods, healthy extras and Syns.

    The phrase "abs are made within the kitchen" isn't an exaggeration and including these fats burning veggies in your food plan will make it easier to reach your physique targets quicker. The best way to general well being is through a diversified, nutrient-rich diet and loads of train However should you're suffering from a bloated belly (and haven't been identified with IBS or a leaky gut), you could be focused on analysis that reveals FODMAP as a possible trigger.

    Throughout the first section of the food plan, designed for speedy weight reduction, you're on a protein-rich weight loss plan, with no restrictions on fat, and a each day carb allowance of 20 to 25g. Low-fat low-Gi food plan including hello-carb, high protein and vegetarian choices plus a daily exercise plan. The amount of processed meat, pink meat and saturated fats in the sort of food regimen is a problem, as is the recommendation to add salt.

    This can be a graph from a examine evaluating low-carb and low-fat diets in chubby or overweight girls (). It is simple to seek out healthy foods to include on a weight loss food regimen. One of the best weight loss program for losing a few pounds is one that is good for all parts of your body, out of your mind to your toes, and never just to your waistline. They have several properties that make them excellent for a weight reduction weight-reduction plan, http://it.bedwetters.eu/ akin to being low in energy and carbohydrates and loaded with fiber.

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    2 days ago
  • As an alternative of following a fad food regimen or a over-exercising in an try and shed pounds, there is a much healthier resolution: Incorporate meals into your diet that facilitate a high metabolism, consistent vitality, and http://fr.maribor2013.eu/ prolonged satiation. Numerous research present that meals and diets with a low vitality density make folks eat fewer calories total (). That is confirmed to make you lose as much as 2-three times as a lot weight as a typical low-fats, calorie-restricted food regimen ( 38 , 39 , ). Slimming World focuses on Food Optimising, which consists of three steps: free meals, wholesome extras and Syns.

    The primary benefit of the low-carb weight-reduction plan is that it causes you to want to eat less Even with out counting calories most obese people eat far fewer energy on low carb. The LighterLife weight loss plans combine a very low-calorie food regimen (VLCD) with weekly counselling. Meal-alternative diets can be effective at serving to some individuals lose weight and maintain it off.

    The primary advantage of the low-carb weight loss plan is that it causes you to want to eat less Even without counting calories most overweight folks eat far fewer calories on low carb. The LighterLife weight reduction plans combine a very low-calorie weight loss program (VLCD) with weekly counselling. Meal-replacement diets will be effective at serving to some folks lose weight and keep it off.

    Slimming World presents a generous ‘no-hunger' eating plan to make slimming easier than you ever thought possible! The idea is that an alkaline eating regimen helps preserve the physique's acidity at wholesome ranges. With so many eating regimen choices to choose from, it may be arduous to find a weight reduction plan to go well with you. Your physique can convert fats to carbohydrates and vice versa so altering the proportion of every in your eating regimen in an attempt to drop a few pounds is rendered ineffective.

    Older adults have unique nutritional wants and will have to make adjustments to their diets as the years go by. Muscle mass can decrease as a pure a part of aging, and folks do not burn energy on the similar rate as they do during their younger years. Thanks partially to its high dietary fibre content material, it promotes wholesome digestion, lowering swelling in the physique, flushing out toxins and excess fluids.

    The phrase "abs are made in the kitchen" just isn't an exaggeration and http://it.it.natura2000net.eu/ including these fats burning veggies in your food plan will allow you to reach your body goals faster. One of the best ways to total well being is through a varied, nutrient-wealthy diet and http://natura2000net.eu/ plenty of train But when you're suffering from a bloated stomach (and haven't been identified with IBS or a leaky gut), you is likely to be fascinated by analysis that reveals FODMAP as a potential cause.

    Slimming World is a UK-primarily based weight reduction organisation that gives life-style weight management programmes. Once you get past the initial phase, the weight loss program follows the essential rules of wholesome eating and should present the vitamins it's essential to keep healthy. The eating regimen and exercise plans supply a balanced strategy to weight loss that teaches you about portion dimension, the importance of standard exercise and making more healthy choices.

    Not like the Atkins food plan, Dukan's phase 1 bans vegetables and critically restricts fats. A new research has revealed that a weight loss program rich in protein and low in energy may help older adults with obesity lose extra weight whereas sustaining muscle mass and enhancing bone density. Abstract Although fruits comprise some sugar, you'll be able to simply embody them on a weight loss food plan.

    Latest human and canine research present that the omega-three fatty acids EPA and DHA from fish oil promote weight loss and assist dieters really feel more satisfied. At first of the food plan, you could expertise unwanted side effects similar to bad breath, a dry mouth, tiredness, dizziness, http://it.hollandhillsclassic.eu/ insomnia and nausea from slicing out carbs. Combining a low-fat, low glycemic-index eating regimen with exercise.

    Slimming World's weight reduction plan encourages you to swap high-fats foods for naturally filling low-fat ones. Low in calories and excessive in fibre, http://se.logisticsqualifications.eu/ pumpkin is without doubt one of the greatest greens to incorporate in your weight loss weight loss program. Carrots are top-of-the-line low-calorie greens to incorporate in your weight loss food plan. There are lots of research that show that adding train to diets could be useful.

    Two days a week on a restricted weight loss plan can lead to larger reductions in physique fats, insulin resistance and other continual ailments. Another common mistake when eating a low-carb food regimen is getting fooled by the creative marketing of particular low-carb" merchandise. As mentioned above, meals and diets with a low energy density are likely to make people eat fewer energy.

    Through the first part of the food regimen, designed for fast weight loss, you are on a protein-wealthy weight-reduction plan, with no restrictions on fat, and a day by day carb allowance of 20 to 25g. Low-fat low-Gi weight loss program including hi-carb, excessive protein and vegetarian choices plus a daily train plan. The quantity of processed meat, red meat and saturated fats in this sort of weight loss program is a problem, as is the recommendation to add salt.

    Read More...
    4 days ago

  • 0 of 0 people found the following review helpful

    Health & Wellness Average overall rating: 2.8
    Sunday, 15 September 2019

    Written by Anonymous

    Overall rating
    4.7
    Low side effects
    5.0
    Length of effects
    5.0
    Low development of tolerance
    5.0
    Low dependence
    5.0
    Immune system enhancer
    4.5
    Safety
    5.0
    Digestive aid
    4.0
    Value for money
    5.0
    Miracle Mineral Solution (MMS) MMS got rid of all my joint pains in approx 3 weeks and also my sun hives which would appear at the beginning of every summer. What is important to note about MMS is that the formula for it changed. When I first used it around 2010 it was two liquids mixed together, one of those liquids was 50% Citric Acid. This has now been replaced by 4% HCL - Hydrochloric Acid. The old formula with 50% Citric Acid caused a lot of stomach upset, whilst the new formula with 4% Hydrochloric Acid aids digestion.

    Also the way people are told to take MMS has changed - instead of very high doses, people are now encouraged to have very low dosages - usually upto a maximum of 3 drops per hour for upto 8 hours a day.

    A lot of the negative reviews of MMS were from the use of 50% Citric Acid - taking it with 4% HCL makes MMS much more gentle on the body. As others have said, when I first used MMS I noticed I was flushing out many strange things from my body in my stools. Some of which may have been parasites.

    I also believe I flushed out mercury from my body from years of dentist fillings as a child. The smell I would get of my stools was exactly the same smell as being in the dentist chair having a new filling put in. I think accumulated mercury might have been the reason I had sun hives every summer and once flushed out the sun hives just went away and stayed away. Before MMS I had to be covered in head to toe with long sleeves or sun cream - now I can walk in the sun with shorts and a T-Shirt and no sun screen and I'm totally fine, I never burn now.

    With regards to joint pains - my wrists used to click and my toes would click when walking, within 3 days of taking MMS the clicking stopped.

    For those of you considering taking MMS use the version with 4% HCL in it not 50% Citric Acid and most of the negative things you read about MMS won't apply.
    Was this review helpful to you? yes     no
    2 months ago
  • a Guest added a new review for NuCare Creatine Power Tabs

    0 of 0 people found the following review helpful

    Muscle & Strength Average overall rating: 4.6
    Saturday, 19 January 2019

    Written by Anonymous

    Overall rating
    4.6
    Alertness
    5.0
    Muscle gain
    5.0
    Strength
    5.0
    Physical energy
    5.0
    Low side effects
    2.0
    Recovery ability
    5.0
    Pump
    5.0
    Increased appetite
    5.0
    Taste
    5.0
    Mixes well
    1.0
    Safety
    5.0
    Value for money
    5.0
    Creatine Power Tabs I use to take the NuCare powertabs two, what can I say it worked. I got really big huge gains from it, but what I want to know are the new powertabs the same as the old ones that had came out like over 18 years ago
    Was this review helpful to you? yes     no
    10 months ago

  • 1 of 1 people found the following review helpful

    Meal Replacement & Protein Average overall rating: 2.5
    Monday, 23 January 2017

    Written by Anonymous

    Overall rating
    3.2
    Muscle gain
    3.0
    Strength
    2.5
    Taste
    5.0
    Mixes well
    3.0
    Safety
    3.0
    Suppressed appetite
    5.0
    Increased appetite
    0.5
    Recovery ability
    3.0
    Low side effects
    4.0
    Physical energy
    4.0
    Value for money
    4.0
    Ingredient profile
    2.5
    Recover Whey Protein Bar This is the best tasting protein bar that I have had. I do not eat these for the workout recovery but for the protein and suppressed appetite.
    Was this review helpful to you? yes     no
    3 years ago
  • admin updated a review for Listerine Listerine Zero

    2 of 2 people found the following review helpful

    Health & Wellness Average overall rating: 1.4
    Wednesday, 21 September 2016

    Written by admin - Top 50 reviewer - View all my reviews

    Overall rating
    1.4
    Low side effects
    0.5
    Taste
    4.0
    Safety
    0.5
    Value for money
    0.5
    Ingredient profile
    0.5
    Listerine Zero There isn’t a proper category for this product, as it’s not a supplement. However, I felt compelled to provide a review of it.

    It’s a litlte strange how Listerine Zero got such high reviews and ratings on the Canadian Listerine site (http://www.listerine.ca/products/classic-clean/classic-clean-zero), but not anywhere close on the .com site (https://www.listerine.com/mouthwash/alcohol-free/listerine-zero-mouthwash), where it garnered 1 out of 5 stars for 41 of the 126 reviews. One wonders why…

    I started searching the reviews after I had been given a free sample and started using it, and getting some nasty effects that I could liken to another product I had used years earlier. That product was Miracle Mineral Solution (MMS for short), which I reviewed here: http://www.supplementarium.com/supplements/817-miracle-mineral-solution-mms/reviews.

    MMS is basically sodium chlorite, an industrial cleaning agent. I found that it caused the tissues in my mouth to slough off, and I could literally feel them coming off on my tongue as I ran my tongue along the sides of my mouth. A similar thing happened with Listerine Zero. If you look at the ingredients, it has sodium lauryl sulfate (SLS) listed as an “inactive ingredient”. Supposedly, the “4 essential signature oils” comprise the active ingredients, and are responsible for keeping one’s breath fresh. I would argue that it’s the sodium lauryl sulfate that is doing most of the work, killing the bacteria - and, unfortunately, destroying other good tissue in the process.

    Even the top positive review on Amazon (https://www.amazon.com/product-reviews/B003QH1P6W/ref=cm_cr_arp_d_hist_1?pageNumber=1&filterByStar=one_star) mentions "possible mouth peeling", and there are plenty of negative reviews there that describe the skin peeling effects.

    Another reviewer on the Listerine.com site identified SLS as the cause of huge chunks of cheek and gum tissue to be coming off; it was also confirmed by this reviewer’s dentist. SLS is an industrial detergent and known irritant, which you can read more about here: http://slsfree.net (and many other sites, if you search around).

    All that Johnson and Johnson, the company behind this product, would respond to these negative reviews was how they want to gather additional information from and speak with the reviewers directly. However, that was over a year ago, and the product is still on our supermarket shelves, being bought and used by the unsuspecting public. I find it utterly disgraceful that such a dangerous product is allowed to be sold.

    Use Listerine Zero at your peril!
    Was this review helpful to you? yes     no
    3 years ago
  • admin added a new review for Listerine Listerine Zero

    2 of 2 people found the following review helpful

    Health & Wellness Average overall rating: 1.4
    Wednesday, 21 September 2016

    Written by admin - Top 50 reviewer - View all my reviews

    Overall rating
    1.4
    Low side effects
    0.5
    Taste
    4.0
    Safety
    0.5
    Value for money
    0.5
    Ingredient profile
    0.5
    Listerine Zero There isn’t a proper category for this product, as it’s not a supplement. However, I felt compelled to provide a review of it.

    It’s a litlte strange how Listerine Zero got such high reviews and ratings on the Canadian Listerine site (http://www.listerine.ca/products/classic-clean/classic-clean-zero), but not anywhere close on the .com site (https://www.listerine.com/mouthwash/alcohol-free/listerine-zero-mouthwash), where it garnered 1 out of 5 stars for 41 of the 126 reviews. One wonders why…

    I started searching the reviews after I had been given a free sample and started using it, and getting some nasty effects that I could liken to another product I had used years earlier. That product was Miracle Mineral Solution (MMS for short), which I reviewed here: http://www.supplementarium.com/supplements/817-miracle-mineral-solution-mms/reviews.

    MMS is basically sodium chlorite, an industrial cleaning agent. I found that it caused the tissues in my mouth to slough off, and I could literally feel them coming off on my tongue as I ran my tongue along the sides of my mouth. A similar thing happened with Listerine Zero. If you look at the ingredients, it has sodium lauryl sulfate (SLS) listed as an “inactive ingredient”. Supposedly, the “4 essential signature oils” comprise the active ingredients, and are responsible for keeping one’s breath fresh. I would argue that it’s the sodium lauryl sulfate that is doing most of the work, killing the bacteria - and, unfortunately, destroying other good tissue in the process.

    Even the top positive review on Amazon (https://www.amazon.com/product-reviews/B003QH1P6W/ref=cm_cr_arp_d_hist_1?pageNumber=1&filterByStar=one_star) mentions "possible mouth peeling", and there are plenty of negative reviews there that describe the skin peeling effects.

    Another reviewer on the Listerine.com site identified SLS as the cause of huge chunks of cheek and gum tissue to be coming off; it was also confirmed by this reviewer’s dentist. SLS is an industrial detergent and known irritant, which you can read more about here: http://slsfree.net (and many other sites, if you search around).

    All that Johnson and Johnson, the company behind this product, would respond to these negative reviews was how they want to gather additional information from and speak with the reviewers directly. However, that was over a year ago, and the product is still on our supermarket shelves, being bought and used by the unsuspecting public. I find it utterly disgraceful that such a dangerous product is allowed to be sold.

    Use Listerine Zero at your peril!
    Was this review helpful to you? yes     no
    3 years ago
  • Bull Terrier replied to the topic 'Why did datbtrue not allow his site to continue?' in the forum.
    Saying that the moderators don't have admin rights and thus are unable to retrieve the content of the datbtrue forum is just conjecture.
    It could be true, but outside of Dat and the moderators themselves I don't know how anybody else could possibly know.
    I'm quite sure of one thing though - at least one of the moderators has clear intentions to set up another forum and get back the old datbtrue members.

    Read More...
    3 years ago
  • admin replied to the topic 'Why did datbtrue not allow his site to continue?' in the forum.
    Bull Terrier wrote:
    I think that Datbtrue has done enough for plenty of people to merit a bit of trust and good faith. If he says he's closing for serious health problems i think we should believe him.
    As for archiving the site, this is being done by his moderators and they intend to get forum members onto another forum.
    I have no reason to doubt good faith of Datbtrue.

    We don't know yet though, whether admin rights were given to the moderators so that they can retrieve the content. Some people have said that this wasn't done, hence the topic of this thread.

    I should have stated more clearly that the topic is more about why the content wasn't allowed to continue, as in, to be moved to another site. We all know that the original site was being shut down.

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    3 years ago
  • Bull Terrier replied to the topic 'Why did datbtrue not allow his site to continue?' in the forum.
    I think that Datbtrue has done enough for plenty of people to merit a bit of trust and good faith. If he says he's closing for serious health problems i think we should believe him.
    As for archiving the site, this is being done by his moderators and they intend to get forum members onto another forum.
    I have no reason to doubt good faith of Datbtrue.

    Read More...
    3 years ago
  • admin replied to the topic 'Why did datbtrue not allow his site to continue?' in the forum.
    As of today, www.datbtrue.co.uk has been wiped off the DNS database. It's not coming back, even temporarily.

    Read More...
    3 years ago
  • admin replied to the topic 'Why did datbtrue not allow his site to continue?' in the forum.
    Unfortunately I don't believe that anybody was able to archive the site. He closed it down yesterday - one day earlier than originally planned - quite possibly to prevent anybody from doing this.

    It's sad that such a vast body of knowledge contributed by Dat - as well as many others - could very well be lost.

    Losing not only this knowledge, but the person behind it all, is a terrible blow to all of humanity.

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    3 years ago
  • admin replied to the topic 'Why did datbtrue not allow his site to continue?' in the forum.
    There's a thread on Reddit going on about this too: www.reddit.com/r/bodybuilding/comments/5...or_visited_datbtrue/.

    Someone posted a good comment there on why he might have shut it down so suddenly. It could be that he didn't have much faith in all the research he had done, his illness still progressed to the point it's at now. Who knows, he may have thought that his use of the IGF-1 LR3 hastened the illness?

    So he could have pulled the plug with the notion that other people don't get misinformed on the benefits of IGF-1, etc.

    Read More...
    3 years ago
  • kkc36392 replied to the topic 'Why did datbtrue not allow his site to continue?' in the forum.
    It would be such a shame to see it disappear :(

    My speculation is that it is already sold or passed on to another site or someone has bought the rights to the material already??

    Read More...
    3 years ago
  • admin created a new topic ' Why did datbtrue not allow his site to continue?' in the forum.
    This thread is about the controversy surrounding Datbtrue's site - datbtrue.co.uk - why do you think he didn't give the credentials to a mod or two to either allow it to continue, or to have the content from it archived or passed onto another site?

    No doubt some people will say it's because of legal issues. Let's hear your thoughts!

    Read More...
    3 years ago
  • Bull Terrier replied to the topic 'Testosterone and Anavar' in the forum.
    I'm calling BS on the article pulled from steroidology in opening post. Stanozolo has been shown to increase collagen synthesis (www.ncbi.nlm.nih.gov/pubmed/9856839) but I can't find any credible information in scientific literature that testosterone inhibits collagen synthesis. Actually if anything it has a positive effect:

    www.ncbi.nlm.nih.gov/pubmed/1529802
    "Abstract
    Testosterone and its metabolite 5 alpha-dihydrotestosterone (DHT) were compared with dexamethasone 21-acetate in two different animal models of arthritis and found to have effects on cartilage breakdown and inflammation. In the mouse air pouch, at the three dose levels used, significant effects were obtained with DHT and were more pronounced on cartilage breakdown than on inflammation. At the lowest dose of 0.3 mg kg-1 there was a 64% inhibition of collagen breakdown and 18% inhibition of glycosaminoglycans (GAGs) breakdown. In the antigen-induced arthritis mouse model testosterone had significant inhibitory effects on inflammation (synovial hyperplasia) and cartilage erosion."

    www.ncbi.nlm.nih.gov/pmc/articles/PMC3975417/
    "........The notion that testosterone decreases joint laxity is further supported by the reported increase in the collagen content of the prostate, breast and capsular tissue and an increase in knee ligament repair strength by testosterone "

    Personally I would be surprised if there were to be any information in scientific literature investigating the effect of boldenone and collagen synthesis in humans, considering that it is a veterinary drug.

    Read More...
    4 years ago
  • repellent replied to the topic 'IGF1 vs IGF1 LR3' in the forum.
    www.ncbi.nlm.nih.gov/pubmed/12746901

    These findings reveal a new paradigm by which IGF-1 influences chondrocyte metabolism, by reversing the IL-1-mediated catabolic pathway through up-regulation of its decoy receptor.

    Read More...
    4 years ago
  • repellent replied to the topic 'FGF-18 stimulates intestinal proliferation' in the forum.
    Yes I agree this is systemic

    Read More...
    4 years ago
  • admin created a new topic ' FGF-18 stimulates intestinal proliferation' in the forum.
    FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation
    To examine its biological activity in vivo, rMuFGF-18 was injected into normal mice and ectopically overexpressed in transgenic mice by using a liver-specific promoter. Injection of rMuFGF-18 induced proliferation in a wide variety of tissues, including tissues of both epithelial and mesenchymal origin. The two tissues which appeared to be the primary targets of FGF-18 were the liver and small intestine, both of which exhibited histologic evidence of proliferation and showed significant gains in organ weight following 7 (sometimes 3) days of FGF-18 treatment. Transgenic mice that overexpressed FGF-18 in the liver also exhibited an increase in liver weight and hepatocellular proliferation. These results suggest that FGF-18 is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine.

    This had me a little worried until I read the full text:
    Treatments consisted of intraperitoneal injections with either 5 mg of rMuFGF-18 or vehicle per kg.

    So we're talking about injection into an area that will likely cause a more systemic reaction, and a dose that is orders of magnitude higher than what is used to regenerate cartilage in knees, for instance (where it is injected IA).

    Not too much of a cause for concern IMO.

    Read More...
    4 years ago
  • admin replied to the topic 'Testosterone and Anavar' in the forum.
    Here's a couple of good pieces of info I found (thanks to your private message):

    First a patent:

    Uses of oxandrolone
    The subject invention additionally provides a method of promoting cartilage repair in a patient which comprises administering an oxandrolone to the patient.
    EXAMPLE 1: The effect of oxandrolone on inflammation

    The rat model of carrageenan-induced paw edema is used to assay the anti-inflammatory activity of oxandrolone. In this model, rats are given a sub-plantar injection of carrageenan into the left hind paw. The paw volume is measured by a Hg-displacement volumeter before and at hourly intervals after paw injection. Rats are divided into three groups. One group receives a subcutaneous injection of oxandrolone long before carrageenan administration. A second group receives a subcutaneous injection of oxandrolone closer to carrageenan administration. The other group does not receive any pretreatment and serves as a control.

    The swelling response is reduced indicating efficacy of oxandrolone as an anti-inflammatory agent.

    EXAMPLE 2 : The effect of oxandrolone on Synovial Inflammation

    As a model for synovial inflammation and the ability of oxandrolone to inhibit such inflammation, the knee-joint (synovial) inflammation model in rats is utilized. (Ginsburg et al . , in "Bayer-Symposium VI: Experimental Models of Chronic Inflammatory Diseases", 256-299, 1977, Springer-Verlag) .

    In this model, inflammation is induced by intraarticular injection of bacterial lipopolysaccharide endotoxin (LPS) . The degree of inflammation is reflected by the swelling of the synovial tissue and is measured as the increase in weight postadministration. The LPS toxin and oxandrolone are co-administered.

    The LPS-induced synovial inflammation is inhibited which indicates efficacy of oxandrolone as an inhibitor of synovial inflammation.

    EXAMPLE 3: The effect of Oxandrolone on Adjuvant-Induced Arthritis

    The induction of joint inflammation in rats by administration of Freund's adjuvant is considered to be the model of choice for experimental rheumatoid arthritis (Newbould (1963), Brit. J. Pharmacol. 21: 127). An injection of the adjuvant (Freund's adjuvant with killed Mycobacterium Tuberculosis) into the foot pad results in an initial swelling of the paw, reaching a plateau after 3 days, followed after 14 days by a second increase in,paw and joint swelling, which persists for another 7-10 days. The second phase is regarded as the phase of immunologically- induced chronic arthritis. To examine the efficacy of oxandrolone as an anti-arthritic drug, oxandrolone is given subcutaneously (in doses expressed as mg per kg body weight) to adjuvant-treated rats during 14-21 days after adjuvant administration. Oxandrolone is given daily or on alternating days. As a negative control, saline is given subcutaneously to a second group of adjuvant-treated rats.

    Joint inflammation is reduced which indicates efficacy of oxandrolone as an inhibitor of arthritis.

    And if we wish to delve into the mechanisms of its action, there is the following:

    Dynamics of Bone and Cartilage Metabolism: Principles and Clinical Applications
    Androgens have been shown to inhibit IL-6 production by stromal and osteoblastic cells as well as stimulation of osteoclastogenesis by marrow osteoclast precursors [125, 126].

    Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study.
    CONCLUSION: This followup study showed that individuals were more likely to be diagnosed as having RKOA if they had a higher BMI and increased circulating levels of IL-6. These results should stimulate more work on IL-6 as a potential therapeutic target.

    Also found this interesting piece:

    The Role of IL-6 in Osteoarthritis and Cartilage Regeneration
    DISCUSSION
    This study demonstrates the increased presence of IL-6 in the synovial fluid of patients with symptomatic cartilage lesions and OA donors when compared to healthy donors. Furthermore, we demonstrated for the first time that chondrocytes produce high concentrations of IL-6 during regeneration, especially osteoarthritic chondrocytes. However, IL-6 does not seem to play a direct role in cartilage matrix turnover. Furthermore, only in OA chondrocytes, IL-6 does seem to play a role in proliferation, although the effect was
    different in explants in the presence of synovial fluid compared to 3D differentiation by expanded chondrocytes.

    SIGNIFICANCE
    Soluble mediators, including IL-6, in the synovial fluid of knees with symptomatic cartilage defects are thought to cause progression to osteoarthritis and also hamper cartilage regeneration after cartilage surgeries such as autologous chondrocyte implantation. Identifying and targeting those soluble mediators will increase the success of cartilage
    repair surgery and prevent the progression to early osteoarthritis.


    Read More...
    4 years ago

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