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IGF1 has been shown to be anabolic to cartilage in the animal model of OA, I understand IGF1-LR3 has more potency has anyone found any studies using IGF1-LR3 for cartilage regrowth or have any anecdotal experience?
Is this the study you're referring to?
Intra-articular Injection of HB-IGF-1 Sustains Delivery of IGF-1 to Cartilage through Binding to Chondroitin Sulfate
Do you know what the half-life of HB-IGF-1 is? This abstract mentions the half-life of IGF-1 being 8-16 hours in vivo.
yes that's correct, you note that "IGF-1 directly to the joint through fibrin constructs (18–20) have been promising, but rapid clearance of IGF-1 from the joint has prevented intra-articular injections of IGF-1 without a carrier from being effective (9), and has been a limiting factor in delivery methods proposed to date," also IGF1-LR3 has half life of about 20–30 hours (relative to IGF-1's half-life of about 12–15 hours).
Not sure what implications this has yet
The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability.
I think its saying that as we age we have reduced response to dea(1-3), but this doesn't change the fact that we have increased response to des(1-3) IGF-1 in the OA joint, it summarizes with "the mechanism of the reduced response with age cannot be attributed to changes in IGFBP. Age-related changes in IGF receptors or, more likely, age-related alterations in intracellular signal transduction may also be involved."
So my theory is ( and it is just a theory ) that des(1-3)IGF-1 is better for joints than IGF-1; this may also be the case with LR3-IGF1. But Des(1-3) is readily available