Topic-icon Ember Therapeutics phase 2 knee trial

More
2 years 9 months ago #4909

Please Log in or Create an account to join the conversation.

More
2 years 9 months ago #4925

I have reservations about BMP-7, even if the Ember Therapeutics study sounds good superficially.

Here's from the Yano study from Ann Rheum Dis 2013;72:

A novel disease-modifying osteoarthritis drug candidate targeting Runx1

The major action of TD-198946 is distinct from the actions of the above strategies: it strongly induces chondrogenic differentiation of progenitors, as evidenced by a marked increase in the chondrogenic markers type II collagen and aggrecan, and it does this without promoting hypertrophy, which is often and undesirably observed with conventional chondrogenic agents including BMPs,21 TGF-β,13 insulin21 and insulin-like growth factor-1.22

Ember hasn't published anything yet it seems nor mentioned anything about adverse events, so I'm very curious if they came across any of this.

Please Log in or Create an account to join the conversation.

More
2 years 9 months ago #4927

Yes I feel BMP-7 is a powerful drug and just grows anything. There was a company advert which highlighted how excess cartilage from BMP7 had to be removed from the joint (in animal study), but thats the power if it growing tissue. I suppose the trouble in an OA joint is in some parts we have bone where we want cartilage and it may cause excessive bone growth in these areas. Perhaps with surgical intervention, i.e microfracture it may come into it's own, but again just an opinion

Please Log in or Create an account to join the conversation.

Time to create page: 0.071 seconds
Powered by Kunena Forum